Dental Pulp Stem Cells Advance Ischemic Stroke Recovery

ABSTRACT

Dental-Pulp Stem Cells as a Therapeutic Strategy for Ischemic Stroke.
Biomedicines. 2022 Mar 22;10(4):737. doi: 10.3390/biomedicines10040737.

Nito C, Suda S, Nitahara-Kasahara Y, Okada T, Kimura K.

Author information
Department of Neurological Science, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Collaborative Research Center, Laboratory for Clinical Research, Nippon Medical School, Tokyo, Japan.
Division of Molecular and Medical Genetics, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

BACKGROUND: Ischemic stroke causes brain injury by blocking blood flow to the brain. Current treatments are limited, and dental pulp stem cells may offer a new regenerative treatment approach.

METHODS: The authors reviewed basic research, therapeutic mechanisms, clinical trials, and future prospects for dental pulp stem cell therapy in ischemic stroke.

RESULTS: Studies showed that dental pulp stem cells may support brain recovery through anti-inflammatory effects, neuroprotection, angiogenesis, and tissue repair.

CONCLUSIONS: This review showed that dental pulp stem cells may be a promising therapeutic strategy for ischemic stroke. Future studies may help translate these findings into clinical treatments.

PMID: 35453487
PMCID: PMC9032844
DOI: 10.3390/biomedicines10040737