Dental Pulp Stem Cells Advance Pulp Regeneration Strategies

ABSTRACT

Clinical Potential of Dental Pulp Stem Cells in Pulp Regeneration: Current Endodontic Progress and Future Perspectives.
Front Cell Dev Biol. 2022 Apr 11;10:857066. doi: 10.3389/fcell.2022.857066.

Kwack KH, Lee HW.

Author information
Department of Dentistry, Graduate School, Kyung Hee University, Seoul, South Korea.
Department of Pharmacology, School of Dentistry, Graduate School, Institute of Oral Biology, Kyung Hee University, Seoul, South Korea.

BACKGROUND: Dental pulp damage can lead to loss of tooth vitality. Dental pulp stem cells may help regenerate pulp tissue because they can self-renew, differentiate into multiple cell types, and support immune regulation.

METHODS: The authors reviewed current progress in dental pulp regeneration, including stem cell biology, immunomodulation, allogeneic transplantation, and regenerative endodontic approaches.

RESULTS: Studies showed that dental pulp stem cells may support pulp regeneration by promoting tissue repair, vascularization, immune regulation, and dentin-pulp complex formation.

CONCLUSIONS: This review showed that dental pulp stem cells have strong potential for future pulp regeneration therapies. Continued research may help advance their use in regenerative endodontics.

PMID: 35478967
DOI: 10.3389/fcell.2022.857066