Dental Pulp Stem Cells Attenuate Osteoarthritis Progression
ABSTRACT
Clinical-grade Human Dental Pulp Stem Cells Suppressed the Activation of Osteoarthritic Macrophages and Attenuated Cartilaginous Damage in a Rabbit Osteoarthritis Model.
Stem Cell Res Ther. 2021 May 1;12(1):260. doi: 10.1186/s13287-021-02353-2.
Li PL, Lin CY, Lin YC, Ger LP, Chen YC, Chang PJ, Lin SZ, Harn HJ, Chiou TW.
Author information
Bioinnovation Center, Tzu Chi Foundation, Hualien, Taiwan.
Department of Orthopedics, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
BACKGROUND: Osteoarthritis is characterized by chronic inflammation and progressive cartilage degeneration. Dental pulp stem cells may help regulate inflammatory responses and protect joint tissues.
METHODS: The authors evaluated clinical-grade human dental pulp stem cells in osteoarthritic macrophages and a rabbit model of osteoarthritis.
RESULTS: Dental pulp stem cells suppressed osteoarthritic macrophage activation and reduced cartilage damage in the rabbit model. The treatment also improved inflammatory conditions within the affected joint.
CONCLUSIONS: This study showed that dental pulp stem cells may help reduce inflammation and cartilage degeneration associated with osteoarthritis. These findings support continued investigation of DPSC-based therapies for joint repair.
PMID: 33933140
PMCID: PMC8088312
DOI: 10.1186/s13287-021-02353-2