Dental Pulp Stem Cells Demonstrate Capacity to Model Genetic Disorders - A Breakthrough for Genetic Researchers

ABSTRACT

Dental Pulp-Derived Mesenchymal Stem Cells for Modeling Genetic Disorders.
Int J Mol Sci. 2021 Feb 25;22(5):2269. doi: 10.3390/ijms22052269.

Masuda K, Han X, Kato H, Sato H, Zhang Y, Sun X, Hirofuji Y, Yamaza H, Yamada A, Fukumoto S.

Author information
Section of Oral Medicine for Children, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Department of Molecular Cell Biology and Oral Anatomy, Graduate School of Dental Science, Kyushu University, Fukuoka, Japan.
Division of Pediatric Dentistry, Department of Oral Health and Development Sciences, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

BACKGROUND: Dental pulp stem cells (DPSCs) and stem cells from human exfoliated deciduous teeth (SHEDs) are multipotent mesenchymal stem cells that can be collected from extracted or naturally shed teeth.

METHODS: The authors reviewed studies using patient-derived DPSCs and SHEDs to investigate genetic and developmental disorders.

RESULTS: Studies showed that dental pulp stem cells were able to reproduce disease-specific abnormalities in multiple genetic disorders.

CONCLUSIONS: This review showed that DPSCs can serve as useful patient-specific models for studying genetic disorders.

PMID: 33672989
PMCID: PMC7957077
DOI: 10.3390/ijms22052269