Dental Pulp Stem Cells Drive Neuroregenerative Therapeutic Development
ABSTRACT
Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies.
Int J Mol Sci. 2021 Mar 29;22(7):3546. doi: 10.3390/ijms22073546.
Luzuriaga J, Pineda JR, Irastorza I, Uribe-Etxebarria V, García-Gallastegui P, Encinas JM, Unda F, Ibarretxe G.
Author information
Department of Cell Biology and Histology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), Leioa, Spain.
Polimerbio, Donostia-San Sebastián, Spain.
POLYMAT, University of the Basque Country (UPV/EHU), Bilbao, Spain.
Department of Neurology, University of California San Francisco, San Francisco, California, USA.
BACKGROUND: Dental pulp stem cells are neural crest-derived stem cells with strong proliferative and regenerative capabilities. Their biological properties make them attractive candidates for neuroregenerative therapies.
METHODS: The authors reviewed current research on dental pulp stem cells and their application in neurological repair and regeneration.
RESULTS: Studies demonstrated that dental pulp stem cells promote neuroprotection, angiogenesis, neuronal differentiation, and tissue repair. Their secreted neurotrophic factors may also support recovery following neurological injury.
CONCLUSIONS: This review showed that dental pulp stem cells possess significant neuroregenerative potential. Continued research may help advance their use in future neurological therapies.
PMID: 33805573
PMCID: PMC8036729
DOI: 10.3390/ijms22073546