Dental Pulp Stem Cells Enhance Scaffold-Based Bone Regeneration

ABSTRACT

Evaluating the Efficacy of Human Dental Pulp Stem Cells and Scaffold Combination for Bone Regeneration in Animal Models: A Systematic Review and Meta-analysis.
Stem Cell Research & Therapy. 2023;14:116. doi: 10.1186/s13287-023-03357-w.

Namjoynik A., Islam M.

Author information
School of Dentistry, University of Dundee, Dundee, Scotland, United Kingdom.
Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, United Kingdom.
School of Dentistry, University of Dundee, Dundee, Scotland, United Kingdom.

BACKGROUND: Bone regeneration remains a major challenge in regenerative medicine. Human dental pulp stem cells combined with scaffolds may provide a promising strategy for bone repair.

METHODS: The authors conducted a systematic review and meta-analysis of animal studies evaluating human dental pulp stem cells with scaffold materials for bone regeneration.

RESULTS: The review found that human dental pulp stem cells combined with scaffolds improved bone regeneration outcomes in animal models compared with controls.

CONCLUSIONS: This study showed that scaffold-supported dental pulp stem cells may enhance bone regeneration. Future studies may help advance this strategy toward clinical bone repair applications.

PMID: 37189187
PMCID: PMC10186750
DOI: 10.1186/s13287-023-03357-w