Dental Pulp Stem Cells Strengthen Biomaterial-Based Neural Repair Strategies

ABSTRACT

Prevascularized Scaffolds Bearing Human Dental Pulp Stem Cells for Treating Complete Spinal Cord Injury.
Adv Healthc Mater. 2020 Oct;9(20):e2000974. doi: 10.1002/adhm.202000974.

Guo S, Perets N, Betzer O, Ben-Shaul S, Sheinin A, Michaelevski I, Popovtzer R, Offen D, Levenberg S.

Author information
Faculty of Biomedical Engineering, Technion – Israel Institute of Technology, Haifa, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Neuroscience, Tel Aviv University, Tel Aviv, Israel.

BACKGROUND: Successful spinal cord repair requires both neural regeneration and restoration of blood supply.

METHODS: The authors developed prevascularized scaffolds containing human dental pulp stem cells and evaluated them in a rat model of complete spinal cord injury.

RESULTS: The scaffolds promoted vascularization, axonal regeneration, myelin formation, and functional recovery.

CONCLUSIONS: This study showed that combining dental pulp stem cells with biomaterial scaffolds may enhance spinal cord repair.

PMID: 32902147
DOI: 10.1002/adhm.202000974