Dental Pulp Stem Cells Strengthen Functional Pulp Regeneration

ABSTRACT

Functional Dental Pulp Regeneration: Basic Research and Clinical Translation.
Int J Mol Sci. 2021 Aug 20;22(16):8991. doi: 10.3390/ijms22168991.

Xie Z, Shen Z, Zhan P, Yang J, Huang Q, Huang S, Chen L, Lin Z.

Author information
Department of Operative Dentistry and Endodontics, Guanghua Hospital of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.

BACKGROUND: Current treatments for pulp and periapical diseases can resolve symptoms but do not fully regenerate natural pulp tissue. Dental pulp stem cells may help restore the dentin-pulp complex.

METHODS: The authors reviewed biological studies, preclinical models, clinical translation, biomaterials, growth factors, and stem cell-based strategies for functional pulp regeneration.

RESULTS: Studies showed that dental pulp stem cells, combined with biomaterials and growth factors, can support vascularization, innervation, dentin formation, and pulp-like tissue regeneration.

CONCLUSIONS: This review showed that dental pulp stem cells are central to functional pulp regeneration. Future studies may help bring tissue engineering-based endodontic therapies closer to clinical use.

PMID: 34445703
DOI: 10.3390/ijms22168991