Dental Pulp Stem Cells Support Bone Defect Regeneration
ABSTRACT
Dental Pulp Stem Cells for Reconstructing Bone Defects: A Systematic Review and Meta-analysis.
J Dent Res Dent Clin Dent Prospects. 2022;16(4):204-220. doi: 10.34172/joddd.2022.034.
Moeenzade N, Nasirpouri F, Bahrami N, Khazaei M, Jalali M, Mashhadiabbas F.
Author information
Student Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
School of Dentistry, Birjand University of Medical Sciences, Birjand, Iran.
BACKGROUND: Bone defects can be difficult to repair, particularly in oral and maxillofacial applications. Dental pulp stem cells have been investigated as a potential source of regenerative cells for bone reconstruction.
METHODS: The authors systematically searched PubMed, EMBASE, and Scopus databases for preclinical studies evaluating dental pulp stem cells in bone defect regeneration.
RESULTS: Twenty-three studies met the inclusion criteria. Meta-analysis showed that dental pulp stem cells significantly improved new bone formation and enhanced bone defect healing compared with controls.
CONCLUSIONS: This study showed that dental pulp stem cells can support bone defect regeneration. Future studies may help advance their use in bone tissue engineering and regenerative medicine.
PMID: 37560493
PMCID: PMC10407871
DOI: 10.34172/joddd.2022.034