Dental Pulp Stem Cells Support Clinical Translation Into Regenerative Therapies

ABSTRACT

Human Dental Pulp Stem/Stromal Cells in Clinical Practice.
World Journal of Stem Cells. 2024 Feb 26;16(2):54-57. doi: 10.4252/wjsc.v16.i2.54.

Grawish ME.

Author information
Department of Oral Biology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.

BACKGROUND: Human dental pulp stem/stromal cells have attracted considerable attention due to their accessibility, regenerative capacity, and ability to differentiate into multiple cell types.

METHODS: The author reviewed current clinical applications and translational studies involving DPSCs and stem cells from human exfoliated deciduous teeth (SHEDs).

RESULTS: Clinical and preclinical studies demonstrated promising outcomes in pulp regeneration, periodontal regeneration, ischemic stroke treatment, and craniofacial tissue repair. The review also summarized ongoing efforts to translate DPSC therapies into routine clinical practice.

CONCLUSIONS: This review highlights the growing clinical relevance of dental pulp stem/stromal cells and supports continued development of regenerative therapies utilizing these cells.

PMID: 38455102
PMCID: PMC10915954
DOI: 10.4252/wjsc.v16.i2.54