Dental Pulp Stem Cells Support Retinal Degeneration Recovery
ABSTRACT
Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Retinal Degeneration.
Tissue Engineering and Regenerative Medicine. 2021 Apr;18(2):143-159. doi: 10.1007/s13770-020-00312-1.
Abdullah M, Ng MH, Abu Kasim NH, Yusof N, Kamarudin TA, Sulong S, Yahaya BH, Mok PL.
Author information
Faculty of Medicine, Department of Ophthalmology, UKM Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Department of Medical Microbiology and Parasitology, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Department of Biomedical Science, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
Tissue Engineering Centre, UKM Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Aljouf Province, Saudi Arabia.
Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
BACKGROUND: Retinal degeneration is a major cause of irreversible vision loss and blindness worldwide. Current treatments are limited in their ability to restore damaged retinal tissue.
METHODS: The authors reviewed published studies investigating the use of dental pulp stem cells for retinal degeneration.
RESULTS: Studies showed that dental pulp stem cells secrete neurotrophic factors that support retinal cell survival and tissue repair, reduce inflammation, and promote neuroprotection.
CONCLUSIONS: This review showed that dental pulp stem cells possess significant potential for treating retinal degenerative diseases.
PMID: 33415670
PMCID: PMC786247
DOI: 10.1007/s13770-020-00312-1